Nifedipine__L-type Ca channel blocker Motesanib
Product Name
Nifedipine
Description
L-type Ca channel blocker
Purity
>98%
CAS No.
21829-25-4
Molecular Formula
C17H18N2O6
Molecular Weight
346.34
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
Yellow solid
SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2N+(=O)O-)C(=O)OC
InChI
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChIKey
HYIMSNHJOBLJNT-UHFFFAOYSA-N
Safety Phrases
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
R60 – May impair fertility
R61 – May cause harm to the unborn child
Hazard Phrases: H302
Cite This Product
Nifedipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-309)
Alternative Names
Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate
Research Areas
Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
PubChem ID
4485
Scientific Background
Nifedipine is a dihydropyridine calcium channel blocker. It is used mainly as an antianginal, and hypertensive (1), but has other uses such as Raynaud’s phenomenon (2), premature labor, and painful spasms of the esophagus.
References
1. Dalal J.J., Griffiths B.E. and Henderson A.H. (1981) Br Heart J. 46(2): 230-231.
2. Thompson A.E., Pope J.E. (2005) Rheumatology. 44(2): 145-150.
L-type Ca channel blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
R60 – May impair fertility
R61 – May cause harm to the unborn child
Hazard Phrases: H302
2. Thompson A.E., Pope J.E. (2005) Rheumatology. 44(2): 145-150.