Nigericin

Nigericin__NALP3 activator WEHI-540 (hydrochloride)

Product Name	Nigericin
Description	NALP3 activator
Purity	>98%
CAS No.	28643-80-3
Molecular Formula	C40H67NaO11
Molecular Weight	746.94

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inducer
Solubility	Soluble to 50 mM in DMSO and 20 mM in ethanol
Source	Synthetic
Appearance	White to off-white Solid
SMILES	Cemail protected1CCC@@H(Oemail protected1C@@H(C)C(=O)O)CC@@H2Cemail protected(email protected(C@@3(O2)C@@H(CC@@(O3)(C)email protected4CCC@@(O4)(C)email protected5email protected(CC@@H(O5)C@@H6email protected(Cemail protected(C@@(O6)(CO)O)C)C)C)C)C)OC
InChI	InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-3
InChIKey	DANUORFCFTYTSZ-SJSJOXFOSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302
Cite This Product	Nigericin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-229)

Alternative Names	(2R)-2-(2R,3S,6R)-6-{(2S,4R,5R,7R,9R,10R)-2-{(2S,2'R,3'S,5R,5'R)-5'-(2S,3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-metho xy-2,4,10-trimethyl-1,6-dioxaspiro4.5dec-7-ylmethyl}-3-methyltetrahydro-2H-pyran-2-ylpropanoic acid
Research Areas	Cancer, Apoptosis
PubChem ID	23681158
Scientific Background	Nigericin acts as a K and Na ionophore. It stimulates Ca release from mitochondrial stores by disruption of membrane potential.
References	1. Vercesi A.E., et al. (1993) J Biol Chem. 268: 8564. 2. Graven S.N., Estrada-O, S., Lardy H.A. (1966) Proc Natl Acad Sci USA. 56(2): 654-658.