Nilotinib

Nilotinib__BCR-ABL kinase inhibitor CPI-204

Product Name	Nilotinib
Description	BCR-ABL kinase inhibitor
Purity	>99%
CAS No.	641571-10-0
Molecular Formula	C28H22F3N7O
Molecular Weight	529.5

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in DMSO (50 mg/ml), chloroform, DMF (~3 mg/ml), water(very poorly soluble, maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility), and ethanol(very poorly soluble)
Source	Synthetic
Appearance	Crystalline powder
SMILES	C5=C(N1C=C(N=C1)C)C=C(NC(=O)C2=CC(=C(C=C2)C)NC3=NC(=CC=N3)C4=CN=CC=C4)C=C5C(F)(F)F
InChI	InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
InChIKey	HHZIURLSWUIHRB-UHFFFAOYSA-N
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product	Nilotinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-463)

Alternative Names	4-methyl-N-3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminobenzamide
Research Areas	Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID	644241
Scientific Background	Nilotinib is a potent and selective Bcr/Abl tyrosine kinase inhibitor, as well as, an inhibitor of JAK2/STAT5, and MDM2 at the post-translational level. Nilotinib shows antiproliferative and antitumor effects in vivo.
References	1. Gallipoli P., et al. (2014) Blood. 2. Zhang H., Gu L., Liu T., Chiang K.Y., & Zhou M. (2014) PloS One. 9(6): e100960.