Nonactin__Ammonium ionophore SB-431543
Product Name
Nonactin
Description
Ammonium ionophore
Purity
>98% (TLC)
CAS No.
6833-84-7
Molecular Formula
C40H64O12
Molecular Weight
736.93
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO, methanol, ethanol (10 mM), dichloromethane and ethyl acetate. Insoluble in water.
Source
Synthetic
Appearance
White to off-White solid
SMILES
CC@@H1Cemail protected2CCemail protected(O2)C@@H(C(=O)Oemail protected(CC@@H3CCC@@H(O3)email protected(C(=O)OC@@H(Cemail protected4CCemail protected(O4)C@@H(C(=O)Oemail protected(CC@@H5CCC@@H(O5)email protected(C(=O)O1)C)C)C)C)C)C)C
InChI
InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-
InChIKey
RMIXHJPMNBXMBU-QIIXEHPYSA-N
Safety Phrases
Classification: Toxic.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H335 – May cause respiratory irritation.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 – Wear protective gloves/protective clothing.
P305+P351+P338 – IF IN EYES: rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405 – Store locked up.
P501 – Dispose of contents/container in accordance with local/regional/national/international regulations.
Cite This Product
Nonactin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-372)
Alternative Names
(1R,2R,5R,7R,10S,11S,14S,16S,19R,20¬R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-O¬ctamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo-32.2.1.17,10.116,19.125,28tetracontane-3,12,21,3¬0-tetrone
Research Areas
Neuroscience
PubChem ID
72519
Scientific Background
Nonactin also known as Polynanctin, Werramycin A is a member of the family of cyclic ionophores. It has a high selectivity for ammonium ions and for this reason is also known as “ammonium ionophore”. It was first isolated by Corbaz et al. in 1955 from bacterial strains (1). To understand the required stereochemistry for an efficient bacterial and ion binding, various isothermal calorimetric measurements were performed with K+, Na+ and NH4+. Nonactin is active against a range of gram positive organisms and has a high selectivity for K+ (2).
References
1. Corbaz R., et al. (1955) Helvetica Chimica Acta 38(60): 1445-48.
2. Kushe B., Smith A., McGuirl M., Priestley N., (2009) J Am Chem Soc 131(47): 17555-165.
Ammonium ionophore
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled
H315 – Causes skin irritation.
H319 – Causes serious eye irritation.
H335 – May cause respiratory irritation.
Precautionary Phrases:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 – Wear protective gloves/protective clothing.
P305+P351+P338 – IF IN EYES: rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P405 – Store locked up.
P501 – Dispose of contents/container in accordance with local/regional/national/international regulations.
2. Kushe B., Smith A., McGuirl M., Priestley N., (2009) J Am Chem Soc 131(47): 17555-165.