NPC 15437__PKC kinase inhibitor Quizartinib
Product Name
NPC 15437
Description
PKC kinase inhibitor
Purity
>98% (HPLC)
CAS No.
141774-20-1
Molecular Formula
C25H52Cl2N4O2
Molecular Weight
511.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in water, DMSO or methanol
Source
Synthetic
Appearance
White to off-white solid
SMILES
O=C(N1C(CNC(=O)C@@H(N)CCCCN)CCCC1)CCCCCCCCCCCC.Cl.Cl
InChI
InChI=1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1
InChIKey
RISSBZWRJRRXTD-OLBPYZPGSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
NPC 15437 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-464)
Alternative Names
(S)-2,6-diamino-N-{1'-(1''-oxotridecyl)-2'-piperidinylmethyl}hexanamide . 2HCl
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
16219723
Scientific Background
NPC 15437 is selective inhibitor of protein kinase C (PKC). Specifically, it interacts with regulatory domain at residues 12-42.
References
1. Sullivan J.P., Connor J.R., Shearer B.G., & Burch R.M. (1991) Agents and Actions. 34(1-2): 142–144.
2. Sullivan J.P., Connor J.R., Tiffany C., Shearer B.G., & Burch R.M. (1991) FEBS Letters. 285(1): 120–123.
PKC kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Sullivan J.P., Connor J.R., Tiffany C., Shearer B.G., & Burch R.M. (1991) FEBS Letters. 285(1): 120–123.