Nutlin-3__p53/mdm2 inhibitor Calcipotriol
Product Name
Nutlin-3
Description
p53/mdm2 inhibitor
Purity
>98%
CAS No.
548472-68-0
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 100 mM DMSO and Ethanol
Source
Synthetic
Appearance
Yellow solid
SMILES
CC(C)OC1=C(C=CC(=C1)OC)C2=Nemail protected(email protected(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChI
InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
InChIKey
BDUHCSBCVGXTJM-UHFFFAOYSA-N
Safety Phrases
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product
Nutlin-3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-344)
Alternative Names
(±)-4-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-
dihydro-imidazole
-1-carbonyl-piperazin-2-one
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
PubChem ID
216345
Scientific Background
MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
References
1. Vassilev et al (2004) Science 303: 844.
p53/mdm2 inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
dihydro-imidazole
-1-carbonyl-piperazin-2-one