PHA 665752__MET kinase inhibitor Eliglustat
Product Name
PHA 665752
Description
MET kinase inhibitor
Purity
>98%
CAS No.
477575-56-7
Molecular Formula
C32H34Cl2N4O4S
Molecular Weight
641.61
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 100 mM in DMSO.
Source
Synthetic
Appearance
Yellow solid
SMILES
ClC1=C(C(=CC=C1)Cl)CS(=O)(=O)C3=CC=C2NC(C(/C2=C3)=CC4=C(C(=C(NH4)C)C(=O)N5CCCC@@H5CN6CCCC6)C)=O
InChI
InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,1
InChIKey
OYONTEXKYJZFHA-SSHUPFPWSA-N
Safety Phrases
Classification: Not WHMIS controlled.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
PHA 665752 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-421)
Alternative Names
(2R)-1-5-(Z)-5-(2,6-Dichlorophenyl)methylsulfonyl-1,2-dihydro-2-oxo-3H-indol-3-ylidenemethyl-2,4-dimethyl-1H-pyrrol-3-ylcarbonyl-2-(1-pyrrolidinylmethyl)pyrrolidine
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
10461815
Scientific Background
PHA 665752 is a potent and selective MET kinase, ATP-competitive inhibitor. It has been studied as an antitumor agent because it has been seen to inhibit tumorigenicity and angiogenesis in mouse lung cancer xenografts.
References
1. Puri N., Khramtsov A., Ahmed S., Nallasura V., Hetzel J., Jagadeeswaran R., et al. (2007) Cancer Res. 3529-34.
MET kinase inhibitor
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.