Phenylbutyrate Na__HDAC inhibitor Tenofovir (Disoproxil Fumarate)
Product Name
Phenylbutyrate Na
Description
HDAC inhibitor
Purity
>98%
CAS No.
1716-12-7
Molecular Formula
C10H11NaO2
Molecular Weight
186.18
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble to 1100 mM in water and 100 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
C1=CC=C(C=C1)CCCC(=O)O-.Na+
InChI
InChI=1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
InChIKey
VPZRWNZGLKXFOE-UHFFFAOYSA-M
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Phenylbutyrate Na (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-255)
Alternative Names
Sodium 4-phenylbutanoate, 4-PB
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, HDAC Inhibitors
PubChem ID
5258
Scientific Background
Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of gamma-globin gene (2).
References
1. Batashaw M.L., MacArthur R.B., and Tuchman M. (2001) J Pediatr. 138: S46-54.
2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076.
HDAC inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Melichar B., et al. (1998) Clin Cancer Res. 4:3069-3076.