PJ-34__PARP inhibitor Luliconazole
Product Name
PJ-34
Description
PARP inhibitor
Purity
>98% (HPLC); NMR (conforms)
CAS No.
344458-15-7
Molecular Formula
C17H17N3O2•HCL•H2O
Molecular Weight
331.8
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
May be dissolved in DMSO (30 mg/ml) or water (20 mg/ml)
Source
Synthetic
Appearance
White to yellow solid.
SMILES
CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
InChI
InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)
InChIKey
UYJZZVDLGDDTCL-UHFFFAOYSA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
PJ-34 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-366)
Alternative Names
N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,Ndimethylacetamide . HCl
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, PARP Inhibitors
PubChem ID
4858
Scientific Background
PJ-34 is a selective inhibitor of Poly (ADP-Ribose) polymerase (PARP). Studies have shown that the use of PJ-34 on severe inflammatory diseases, in particular experimental allergic encephalomyelitis (EAE) have contributed to a shift of the immune response from a pro-inflammatory Th1 to anti-inflammatory th2 phenotype (1).
References
1. Scott G., Kean R., Mikheeva., Fabis M., Mabley J.J. (2004) The Journal of Pharmacology and Exp. Therapeutics. 310(3): 1053-1061.
PARP inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection