Puromycin HCl__Translation inhibitor OTSSP168 (hydrochloride)
Product Name
Puromycin HCl
Description
Translation inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
58-58-2
Molecular Formula
C22H29N7O5•2HCl
Molecular Weight
544.43
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml)
Source
Synthetic
Appearance
Off-white powder
SMILES
CN(C)C1=NC=NC2=C1N=CN2email protected3C@@H(C@@H(email protected(O3)CO)NC(=O)email protected(CC4=CC=C(C=C4)OC)N)O
InChI
InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5
InChIKey
RXWNCPJZOCPEPQ-WABMVTPESA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
Puromycin HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-248)
Alternative Names
3'-Deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosyl)aminoadenosine
Research Areas
Cancer, Apoptosis
PubChem ID
5891
Scientific Background
Puromycin is an antibiotic that is a protein synthesis inhibitor that causes premature chain termination during translation taking place in the ribosome. Part of the molecule resembles the 3’ end of the tRNA. It enters the A site and transfers to the growing chain, causing the premature release. It is not selective for either prokaryotes or eukaryotes.
References
1. Azzam and Algranati. (1973) Proc Natl Acad Sci. 70: 3866.
Translation inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection