Roscovitine__p34/cdc2 inhibitor Verubecestat
Product Name
Roscovitine
Description
p34/cdc2 inhibitor
Purity
>95% (HPLC, TLC)
CAS No.
186692-46-6
Molecular Formula
C19H26N6O
Molecular Weight
354.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO
Source
Synthetic
Appearance
White to off-white solid
SMILES
email protected(NC2=NC1=C(N=CN1C(C)C)C(=N2)NCC3=CC=CC=C3)(CO)CC
InChI
InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChIKey
BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Roscovitine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-472)
Alternative Names
2-(R)-9-(1-Methylethyl)-6-(phenylmethyl)amino-9H-purin-2-ylamino-1-butanol, 6-Benzylamino-2-(R)-(1-ethyl)-2-hydroxyethylamino-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Research Areas
Cell Signaling
PubChem ID
160355
Scientific Background
Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating.
References
1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526.
p34/cdc2 inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.