SAHA (Vorinostat)__HDAC inhibitor Tivantinib
Product Name
SAHA (Vorinostat)
Description
HDAC inhibitor
Purity
>98% (TLC); NMR (Conforms)
CAS No.
149647-78-9
Molecular Formula
C14H20N2O3
Molecular Weight
264.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol
Source
Synthetic
Appearance
White Solid
SMILES
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
InChI
InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChIKey
WAEXFXRVDQXREF-UHFFFAOYSA-N
Safety Phrases
Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H341-H360 (Suspected of causing genetic defects)
Precautionary Statements:
P201-P281-P308 + P313
Cite This Product
SAHA (Vorinostat) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-359)
Alternative Names
Suberoylanilide-hydroxamic acid; Vorinostat; N-Hydroxy-N'-phenyloctanediamide
Research Areas
Cancer, Cell Signaling, Epigenetics
PubChem ID
5311
Scientific Background
Potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.
References
1. Vrana J.A., et al., (1999) Oncogene. 18: 7016.
2. Butler L.M., et al., (2002) Proc. Natl. Acad. Sci. USA. 99: 11700.
3. Tang Y., et al., (2012) Cancer Biol. Ther. 2012 13(7): 567-574.
HDAC inhibitor
Safety Phrases:
S22 – Do not breathe dust
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H341-H360 (Suspected of causing genetic defects)
Precautionary Statements:
P201-P281-P308 + P313
2. Butler L.M., et al., (2002) Proc. Natl. Acad. Sci. USA. 99: 11700.
3. Tang Y., et al., (2012) Cancer Biol. Ther. 2012 13(7): 567-574.