SB431542__ALK4,5 and 7 kinase inhibitor Abiraterone
Product Name
SB431542
Description
ALK4,5 and 7 kinase inhibitor
Purity
>98% (HPLC)
CAS No.
301836-41-9
Molecular Formula
C22H16N4O3
Molecular Weight
384.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Source
Synthetic
Appearance
Yellow solid
SMILES
C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChI
InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChIKey
FHYUGAJXYORMHI-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
SB431542 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-511)
Alternative Names
SB 431542, 4-(5-Benzol1,3dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl-benzamide hydrate, 4-4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl-benzamide hydrate
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
4521392
Scientific Background
SB431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor, activin receptor-like kinases. It has been shown to inhibit ALK4, 5, and 7.
References
1. Laping N.J., et al. (2002) Mol. Pharm. 62(1): 58–64.
ALK4,5 and 7 kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.