SC 514__IKK-2 kinase inhibitor FRAX487
Product Name
SC 514
Description
IKK-2 kinase inhibitor
Purity
>98% (TLC)
CAS No.
354812-17-2
Molecular Formula
C9H8N2OS2
Molecular Weight
224.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (>25 mg/ml)
Source
Synthetic
Appearance
Yellow solid
SMILES
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
InChI
InChI=1S/C9H8N2OS2/c10-6-3-7(5-1-2-13-4-5)14-8(6)9(11)12/h1-4H,10H2,(H2,11,12)
InChIKey
BMUACLADCKCNKZ-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 3)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed
Precautionary statements:
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician
Cite This Product
SC 514 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-475)
Alternative Names
4-Amino-2',3'-bithiophene-5-carboxamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
2807869
Scientific Background
SC 514 is a selective and reversible inhibitor of IκB kinase 2 / IKKβ (IKK-2). It has been shown to displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. SC-514 exhibits anti-inflammatory properties. SC 514 is cell permeable.
References
1. Kishore N., et al. (2003) J. Biol. Chem. 278(35): 32861–32871.
2. Baxter A., et al. (2004) Bioorganic Med. Chem. Letters. 14(11): 2817–2822.
IKK-2 kinase inhibitor
Acute toxicity, Oral (Category 3)
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed
Precautionary statements:
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician
2. Baxter A., et al. (2004) Bioorganic Med. Chem. Letters. 14(11): 2817–2822.