SC 79__Akt kinase activator EPZ-5677
Product Name
SC 79
Description
Akt kinase activator
Purity
>97% (NMR)
CAS No.
305834-79-1
Molecular Formula
C17H17ClN2O5
Molecular Weight
364.8
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Activator
Solubility
Soluble to 100 mM in DMSO
Source
Synthetic
Appearance
White solid
SMILES
CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Cl)N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
SC 79 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-512)
Alternative Names
SC-79, SC79, 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Research Areas
Cell Signaling
Scientific Background
SC 79 is an activator of Akt (protein kinase B). Specifically, it has been shown to bind the plecktrin homology (PH) domain of Akt. This mimics the binding of Phosphatidylinositol (3,4,5)-trisphosphates, which induces a conformational change in Akt, that enhances phosphorylation and activation.
References
1. Jo H., et al. (2012) Pro. Nat. Acad. Sci. USA. 109(26): 10581–10586.
Akt kinase activator
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.