Spautin-1

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Spautin-1__Autophagy inhibitor BLU9932

Product Name Spautin-1
Description

Autophagy inhibitor
Purity >98%
CAS No. 1262888-28-7
Molecular Formula C15H11F2N3
Molecular Weight 271.26
Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (15 mg/ml).
Source Synthetic
Appearance White to beige powder.
SMILES c1cc(ccc1CNc2c3cc(ccc3ncn2)F)F
InChI InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChIKey AWIVHRPYFSSVOG-UHFFFAOYSA-N
Safety Phrases Classification: D2B- Toxic Material Causing Other Toxic Effects, Severe eye irritant
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302- Harmful if swallowed.
H318- Causes serious eye damage.
Precautionary statements:
P280- Wear protective gloves/ eye protection/ face protection.
P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Cite This Product Spautin-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-404)
Alternative Names 6-Fluoro-N-(4-fluorophenyl)methyl-4-quinazolinamine
Research Areas Cancer, Autophagy
PubChem ID 51037431
Scientific Background Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.
References 1. Liu J., et al. (2011) Cell. 147(1): 223-34.