Src I1__Src kinase inhibitor 3-O-(2-Aminoethyl)-25-hydroxyvitamin D4
Product Name
Src I1
Description
Src kinase inhibitor
Purity
>98% (TLC)
CAS No.
179248-59-0
Molecular Formula
C22H19N3O3
Molecular Weight
373.4
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (5 mg/ml)
Source
Synthetic
Appearance
Off-white solid
SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OC4=CC=CC=C4)OC
InChI
InChI=1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)
InChIKey
DMWVGXGXHPOEPT-UHFFFAOYSA-N
Safety Phrases
Classification:
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335
Chronic aquatic toxicity (Category 4), H413
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302
Harmful if swallowed.
H315
Causes skin irritation.
H319
Causes serious eye irritation.
H335
May cause respiratory irritation.
H413
May cause long lasting harmful effec
ts to aquatic life.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/ eye protection/ face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supple mental first aid instructions on this label).
P330 Rinse mouth.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash be fore reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant
Cite This Product
Src I1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-478)
Alternative Names
6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine, SKI-1, Src Inhibitor-1
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
1474853
Scientific Background
SrcI1 is a potent and competitive dual site Src kinase inhibitor. It has been shown as a potent inhibitor of the Src and Lck kinase, as well as, VEGFR2 and c-fms. SrcI1 is cell permeable and can induce apoptosis.
References
1. Bain, J., et al. (2007) Biochem. J. 408(3): 297–315.
2. Leung, E. L.H., et al. (2009) Mol. Cancer. Res: MCR. 7(6): 923–932.
Src kinase inhibitor
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335
Chronic aquatic toxicity (Category 4), H413
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H302
Harmful if swallowed.
H315
Causes skin irritation.
H319
Causes serious eye irritation.
H335
May cause respiratory irritation.
H413
May cause long lasting harmful effec
ts to aquatic life.
Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/ eye protection/ face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supple mental first aid instructions on this label).
P330 Rinse mouth.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash be fore reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant
2. Leung, E. L.H., et al. (2009) Mol. Cancer. Res: MCR. 7(6): 923–932.