Staurosporine

Staurosporine__Protein kinase inhibitor AZD-5439

Product Name	Staurosporine
Description	Protein kinase inhibitor
Purity	>98% (TLC); NMR (Conforms)
CAS No.	62996-74-1
Molecular Formula	C28H26N4O3
Molecular Weight	466.54

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 50 mM in DMSO
Source	Synthetic
Appearance	Pale Yellow Solid
SMILES	CC@@12C@@H(C@@H(CC@@H(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
InChI	InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(2
InChIKey	HKSZLNNOFSGOKW-FYTWVXJKSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 – Do not breathe dust S24/25 – Avoid contact with skin and eyes S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H340- H350 Precautionary Phrases: P201-P308 + P313
Cite This Product	Staurosporine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-253)

Alternative Names	(2S,3R,4R,6R)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo12.12.2.12,6.07,28.08,13.015,19.020,27.021,26nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Research Areas	Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID	44259
Scientific Background	Staurosporine is a broad spectrum protein kinase inhibitor with activities ranging from anti-fungal to anti-hypertensive (1). Staurosporine is a typical ATP-competitive kinase inhibitor that binds to many kinases with high affinity, but with little selectivity (2).
References	1. Ruegg U.T., and Burgess G.M. (1989) Trends in Pharm Science. 10(6): 218-220. 2. Karaman M.W., et al. (2008) Nat. Biotechnol. 26(1): 127-132.