STO 609__CAMKK kinase inhibitor BD-AcAc 3
Product Name
STO 609
Description
CAMKK kinase inhibitor
Purity
>98% (TLC)
CAS No.
52029-86-4
Molecular Formula
C21H14N2O5
Molecular Weight
374.3
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (10 mg/ml)
Source
Synthetic
Appearance
Yellow solid
SMILES
CC(=O)O.C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O
InChI
InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
InChIKey
WNRSTFUVBWNELX-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
STO 609 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-479)
Alternative Names
7-Oxo-7H-benzimidazo2,1-abenzdeisoquinoline-3-carboxylic acid, acetate salt
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
16760660
Scientific Background
STO 609 is a potent, competitive and selective inhibitor of Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK). STO 609 has been shown to bind to the CaMKK catalytic domain, consequently inhibiting autophosphorylation. It is a valuable tool for exploring the role of the CaM-KK pathway in various physiological processes. STO 609 is cell-permeable.
References
1. Tokumitsu, H., et al. (2002) J. Biol. Chem. 277(18): 15813–15818.
2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364.
3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.
CAMKK kinase inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364.
3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.