Sunitinib malate__VEGFR, PDGFR kinase inhibitor MK-0774
Product Name
Sunitinib malate
Description
VEGFR, PDGFR kinase inhibitor
Purity
>99%
CAS No.
557795-19-4
Molecular Formula
C22H27FN4O2
Molecular Weight
398.5
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (40 mg/ml)
Source
Synthetic
Appearance
Yellow solid
SMILES
C1=CC2=C(C=C1F)C(/C(N2)=O)=C/C3=C(C(=C(NH3)C)C(NCCN(CC)CC)=O)C
InChI
InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
InChIKey
WINHZLLDWRZWRT-ATVHPVEESA-N
Safety Phrases
Classification:
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity-repeated exposure, Oral (Category 1), H372
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H360 May damage fertility or the unborn child.
H372 Causes damage to organs through prolonged or repeated exposure if swallowed.
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P405 Store locked up.
Cite This Product
Sunitinib malate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-482)
Alternative Names
N-2-(Diethylamino)ethyl-5-(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt, SU 011248, SU 11248, SU112248
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID
5329102
Scientific Background
Sunitinib malate is a receptor tyrosine kinase inhibitor. It has been shown to target VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, c-KIT, FLT3, CSF-1R, Flk-1, and RET.
References
1. Hersey P., et al. (2009) Annals of Oncology: ESMO. 20 Suppl 6: vi35–40.
VEGFR, PDGFR kinase inhibitor
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity-repeated exposure, Oral (Category 1), H372
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H360 May damage fertility or the unborn child.
H372 Causes damage to organs through prolonged or repeated exposure if swallowed.
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
P405 Store locked up.