Teprenone__HSP70 Inducer BEZ236
Product Name
Teprenone
Description
HSP70 Inducer
Purity
>95% (GC)
CAS No.
6809-52-5
Molecular Formula
C23H38O
Molecular Weight
330.6
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in DMSO (30 mg/ml)
Source
Synthetic
Appearance
Colorless Oil
SMILES
CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CCC(=O)C)/C)/C)/C)C
InChI
InChI=1S/C23H38O/c1-19(2)11-7-12-20(3)13-8-14-21(4)15-9-16-22(5)17-10-18-23(6)24/h11,13,15,17H,7-10,12,14,16,18H2,1-6H3/b20-13+,21-15+,22-17+
InChIKey
HUCXKZBETONXFO-NJFMWZAGSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Teprenone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-526)
Alternative Names
Geranylgeranylacetone, GGA, 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one
Research Areas
Cancer, Heat Shock, Cell Signaling, Neuroscience
PubChem ID
5282199
Scientific Background
Teprenone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects) (1, 2). Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression (2). Other studies have shown that it induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice (3, 4).
References
1. Kobayashi T., Ohta Y., Yoshino J and Nakazawa S. (2001) Pharmacol Res. 43(1): 23-30.
2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530.
3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47.
4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.
HSP70 Inducer
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
2. Sambroski P., Grzymislawski M. (2015) Adv Clin Med. 24(3): 525-530.
3. Marunouchi T., Inomata S., Sanbe A., Takagi N., Tanonaka K. (2014) Eur J Pharmacol. 730: 1401-47.
4. Sanbe A., et al. (2009) PLoS One. 4(4): e5351.