Trichostatin A__HDAC inhibitor Ponesimod
Product Name
Trichostatin A
Description
HDAC inhibitor
Purity
>98%
CAS No.
58880-19-6
Molecular Formula
C17H22N2O3
Molecular Weight
302.37
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Source
Synthetic
Appearance
Beige Solid
SMILES
Cemail protected(/C=C(C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChI
InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
InChIKey
RTKIYFITIVXBLE-WKWSCTOISA-N
Safety Phrases
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R68 – Possible risk of irreversible effects
Hazard Phrases:
H302-H312-H315-H317-H319-H332-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
Cite This Product
Trichostatin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-254)
Alternative Names
(2E,4E,6R)-7-4-(Dimethylamino)phenyl-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, HDAC Inhibitors
PubChem ID
444732
Scientific Background
Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression but interfering with the removal of acetyl groups thereby altering the ability of DNA transcription factors to access the DNA inside chromatin (2). It also has anti-cancer properties (3).
References
1. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. (2004) Curr Med Chem. 11(12): 1629-1643.
2. Yoshida, et al. (1990) J Biol Chem. 165: 17174.
3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.
HDAC inhibitor
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22 – Harmful by inhilation, in contact with skin and if swallowed
R68 – Possible risk of irreversible effects
Hazard Phrases:
H302-H312-H315-H317-H319-H332-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
2. Yoshida, et al. (1990) J Biol Chem. 165: 17174.
3. Drummond D.C., et al. (2005) Annu Rev Pharmacol Toxicol. 45: 495-528.