Tunicamycin__Autophagy inducer PT-2387
Product Name
Tunicamycin
Description
Autophagy inducer
Purity
>98% (HPLC) as a mixture of tunicamycin A, B, C and D
CAS No.
11089-65-9
Molecular Formula
C39H64N4O16
Molecular Weight
844.95
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inducer
Solubility
Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm).
Source
Isolated from Streptomyces lysosuperficus
Appearance
White solid.
SMILES
C@@H2(Oemail protected(Oemail protected1OC@@H(C@@H(O)email protected(O)email protected1NC(=O)C)CO)email protected(NC(=O)C=CCC(C)C)C@@H(O)email protected2O)CC(O)email protected4OC@@H
Safety Phrases
Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, D2A- Very Toxic Material Causing Other Toxic Effects, Teratogen- Reproductive hazard
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H300- Fatal if swallowed.
Precautionary statements:
P264- Wash hands thoroughly after handling.
P301 + P310- IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
Cite This Product
Tunicamycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-397)
Alternative Names
Tunicamycin from Streptomyces sp.
Research Areas
Cancer, Autophagy
Scientific Background
As a nucleoside antibiotic, Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. This causes an induction of glucose-regulated protein 78 (GRP78) mRNA expression, which in turn increases ER stress and subsequently induces autophagy.
References
1. Unal E.S., et al. (2008) Biochim Biophys Acta. 1778(6): 1407-14.
2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10.
3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12.
4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35.
Autophagy inducer
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H300- Fatal if swallowed.
Precautionary statements:
P264- Wash hands thoroughly after handling.
P301 + P310- IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10.
3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12.
4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35.