U-74389G__Lipid peroxidation blocker GNE-619 (hydrochloride)
Product Name
U-74389G
Description
Lipid peroxidation blocker
Purity
>99%
CAS No.
153190-29-5
Molecular Formula
C37H50N6O2•C4H4O4
Molecular Weight
726.9
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in 25 mg/ml DMSO, and in 20 mg/ml in ethanol; Insoluble in water
Source
Synthetic
Appearance
White Solid
SMILES
CC@12CC=C3email protected(C@@H1CCC@@H2C(=O)CN4CCN(CC4)C5=NC(=NC(=C5)N6CCCC6)N7CCCC7)CCC8=CC(=O)C=CC@@83C.C(=CC(=O)O)C(=O)O
InChI
InChI=1S/C37H50N6O2.CH4O3S/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-
InChIKey
QZGBZPCDCMUFCW-FRVIMOPGSA-N
Safety Phrases
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
Cite This Product
U-74389G (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-205)
Alternative Names
21-{4-2,6-Di(1-pyrrolidinyl)-4-pyrimidinyl-1-piperazinyl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-2-butenedioate (1:1)
Research Areas
Cancer, Apoptosis
PubChem ID
104933
Scientific Background
U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It prevents organ damage in intestinal cold storage, preservation and reperfusion injury (1-4).
References
1. Ishizaki N., et al. (1997) Transplantation. 63: 202-208.
2. Perna A.M., et al. (1996) Pharmacol Res. 34: 25-31.
3. Palma-Vargas J.M., et al. (1996) J Surg Res. 66: 131-137.
4. Shoskes D.A., Xie Y., Gonzalez-Cadavid N.F. Transplantation. 63: 495-500.
Lipid peroxidation blocker
Safety Phrases:
S22 – Do not breathe dust
S24/25 – Avoid contact with skin and eyes
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection
2. Perna A.M., et al. (1996) Pharmacol Res. 34: 25-31.
3. Palma-Vargas J.M., et al. (1996) J Surg Res. 66: 131-137.
4. Shoskes D.A., Xie Y., Gonzalez-Cadavid N.F. Transplantation. 63: 495-500.