Vatalanib Dihydrochloride__VEGFRK inhibitor SBE-β-CD
Product Name
Vatalanib Dihydrochloride
Description
VEGFRK inhibitor
Purity
96%
CAS No.
212141-51-0
Molecular Formula
C20H17Cl3N4
Molecular Weight
419.7
Storage Temperature
-20ºC
Shipping Temperature
Shipped Ambient
Product Type
Inhibitor
Solubility
Soluble in DMSO (30 mg/ml), ethanol (10 mg/ml) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/ml )
Source
Synthetic
Appearance
Solid
SMILES
C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
InChI
InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
InChIKey
AZUQEHCMDUSRLH-UHFFFAOYSA-N
Safety Phrases
Classification:
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product
Vatalanib Dihydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-484)
Alternative Names
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Research Areas
Cancer, Apoptosis, Cancer Growth Inhibitors, Cardiovascular System, Cell Signaling, Growth Factor Receptor Inhibitors
PubChem ID
22386467
Scientific Background
Vatalanib Dihydrochloride is an inhibitor of Flk, c-Kit and PDGFR-β. It has been shown to inhibit VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival.
References
1. Herbst R.S., Heymach J.V., O’Reilly M. S., Onn A., & Ryan A.J. (2007) Expert Opin. Invest. Drugs. 16(2): 239–249.
VEGFRK inhibitor
Not a hazardous substance or mixture.
Safety Phrases:
S22 – Do not breathe dust.
S24/25 – Avoid contact with skin and eyes.
S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection.