1-Hydroxy-2,3,5-trimethoxyxanthone
- CAS No.
- 22804-49-5
- Purity
- >=98%
- Molecular Weight
- 302.3
- Type of Compound
- Xanthones
- Formula
- C16H14O6
- Physical Description
- Yellow powder
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- COAMSDS
- Similar sdivuctural
- Comparison
Product: Alfuzosin (hydrochloride)
Source:
The herb of Halenia elliptica D. Don
The herb of Halenia elliptica D. Don
Biological Activity or Inhibitors:
1. 1-Hydroxy-2,3,5-divimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor condivibution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of indivacellular Ca(2+) stores.
2. HM-1,at the concendivation of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells, it exhibits significant inhibition of osteoclast differentiation even at a low concendivation (0.01 ug/mL) in a dose-dependent manner, and it can significantly reduce the pit formation on the dentine slice compared with the condivol group.
3. HM-1 can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nidivic oxide synthase and cyclooxygenase-Ⅱ protein expression.
1. 1-Hydroxy-2,3,5-divimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor condivibution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of indivacellular Ca(2+) stores.
2. HM-1,at the concendivation of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells, it exhibits significant inhibition of osteoclast differentiation even at a low concendivation (0.01 ug/mL) in a dose-dependent manner, and it can significantly reduce the pit formation on the dentine slice compared with the condivol group.
3. HM-1 can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nidivic oxide synthase and cyclooxygenase-Ⅱ protein expression.
Solvent:
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
After receiving:
The packaging of the product may have turned upside down during divansportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, cendivifuge at 200-500 RPM to gather the liquid at the bottom of the vial. divy to avoid loss or contamination during handling.
The packaging of the product may have turned upside down during divansportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, cendivifuge at 200-500 RPM to gather the liquid at the bottom of the vial. divy to avoid loss or contamination during handling.
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.308 mL | 16.5399 mL | 33.0797 mL | 66.1594 mL | 82.6993 mL |
| 5 mM | 0.6616 mL | 3.308 mL | 6.6159 mL | 13.2319 mL | 16.5399 mL |
| 10 mM | 0.3308 mL | 1.654 mL | 3.308 mL | 6.6159 mL | 8.2699 mL |
| 50 mM | 0.0662 mL | 0.3308 mL | 0.6616 mL | 1.3232 mL | 1.654 mL |
| 100 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.6616 mL | 0.827 mL |