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GPLGIAGQ

Product Name :
GPLGIAGQ

Description:
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).

CAS:
109053-09-0

Molecular Weight:
711.81

Formula:
C31H53N9O10

Chemical Name:
(2S)-2-{2-[(2S)-2-[(2S,3S)-2-{2-[(2S)-2-{[(2S)-1-(2-aminoacetyl)pyrrolidin-2-yl]formamido}-4-methylpentanamido]acetamido}-3-methylpentanamido]propanamido]acetamido}-4-carbamoylbutanoic acid

Smiles :
CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O

InChiKey:
BLNMYSBCIVAVFK-PFZXUFBWSA-N

InChi :
InChI=1S/C31H53N9O10/c1-6-17(4)26(30(48)36-18(5)27(45)34-14-23(42)37-19(31(49)50)9-10-22(33)41)39-24(43)15-35-28(46)20(12-16(2)3)38-29(47)21-8-7-11-40(21)25(44)13-32/h16-21,26H,6-15,32H2,1-5H3,(H2,33,41)(H,34,45)(H,35,46)(H,36,48)(H,37,42)(H,38,47)(H,39,43)(H,49,50)/t17-,18-,19-,20-,21-,26-/m0/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).|Product information|CAS Number: 109053-09-0|Molecular Weight: 711.81|Formula: C31H53N9O10|Chemical Name: (2S)-2-{2-[(2S)-2-[(2S,3S)-2-{2-[(2S)-2-{[(2S)-1-(2-aminoacetyl)pyrrolidin-2-yl]formamido}-4-methylpentanamido]acetamido}-3-methylpentanamido]propanamido]acetamido}-4-carbamoylbutanoic acid|Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O|InChiKey: BLNMYSBCIVAVFK-PFZXUFBWSA-N|InChi: InChI=1S/C31H53N9O10/c1-6-17(4)26(30(48)36-18(5)27(45)34-14-23(42)37-19(31(49)50)9-10-22(33)41)39-24(43)15-35-28(46)20(12-16(2)3)38-29(47)21-8-7-11-40(21)25(44)13-32/h16-21,26H,6-15,32H2,1-5H3,(H2,33,41)(H,34,45)(H,35,46)(H,36,48)(H,37,42)(H,38,47)(H,39,43)(H,49,50)/t17-,18-,19-,20-,21-,26-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bardoxolone} medchemexpress|{Bardoxolone} Necroptosis|{Bardoxolone} Protocol|{Bardoxolone} In Vitro|{Bardoxolone} manufacturer|{Bardoxolone} Cancer} |Shelf Life: ≥12 months if stored properly.{{Fmoc-Ser(tBu)-OH} medchemexpress|{Fmoc-Ser(tBu)-OH} {Amino Acid Derivatives}|{Fmoc-Ser(tBu)-OH} Activator|{Fmoc-Ser(tBu)-OH} Protocol|{Fmoc-Ser(tBu)-OH} Formula|{Fmoc-Ser(tBu)-OH} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32490699 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GPLGIAGQ is used to trigger PEG deshielding of liposomal carriers, resulting in enhanced cellular internalization.|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Nitric oxide synthase (neuronal) polyclonal antibody

Product Name :
Nitric oxide synthase (neuronal) polyclonal antibody

Sequence:

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Description:

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Additional Information :
| Alternative Name nNOS, NOS I | Application ICC, IF, IHC, WB | Application Notes Detects a band of ~140kDa by Western blot.{{755038-65-4} MedChemExpress|{755038-65-4} Protocol|{755038-65-4} In Vivo|{755038-65-4} manufacturer} | Formulation Liquid.{{1809336-39-7} site|{1809336-39-7} Purity & Documentation|{1809336-39-7} In stock|{1809336-39-7} custom synthesis} In PBS containing 1mg/ml BSA and 0.PMID:30020636 05% sodium azide. | Host Rabbit | Immunogen Synthetic peptide corresponding to aa 1411-1425 (CN1411RLRSESIAFIEESK1425) of human neuronal nitric oxide synthase (nNOS; NOS I). This sequence is completely conserved in human, mouse, rat, rabbit and frog nNOS. | Recommendation Dilutions/Conditions Immunocytochemistry (1:50-1:500)Immunofluorescence (1:50-1:500)Immunohistochemistry (1:20-1:200)Western blot (1:100-1:1000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human, Mouse, Rat | UniProt ID P29475 | Unit of Measure (UM) µg

NEDD8 (human), (recombinant) (biotin conjugate)

Product Name :
NEDD8 (human), (recombinant) (biotin conjugate)

Sequence:

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Molecular Weight:
~11kDa (based on Bt3-NEDD8 as predominant form present).

Solubility :

Appearance:

Use/Stability :
Stable for at least 12 months after receipt when stored at -20°C.

Description:
Biotinylated NEDD8 is a useful reagent for studying NEDDylation in vitro, where it represents a readily detectable alternative to radio-iodinated NEDD8. Biotinylated NEDD8 is activated by NEDD8 E1, is a competent substrate for the NEDD8 E2 conjugating enzyme UbcH12 and can be conjugated to target proteins in the presence of a suitable NEDD8 E3 ligase.{{16980-89-5} site|{16980-89-5} Technical Information|{16980-89-5} In Vivo|{16980-89-5} supplier} The biotinyl moiety also provides a potential route to affinity purification of conjugated substrates (or thiol ester-linked enzymes) on avidin/streptavidin matrices.{{1219168-18-9} medchemexpress|{1219168-18-9} Technical Information|{1219168-18-9} In stock|{1219168-18-9} custom synthesis} NEDD8 contains 9 lysine residues, any/many of which are likely to be biotinylated in this product. These modification sites have not been mapped. Biotinylated NEDD8 is prepared from recombinant human His-tagged NEDD8 . Western blot of biotinylated-NEDD8 thioester assay. Bt-NEDD8 conjugated to UbcH12 in the presence of NEDD8 E1 .PMID:31334949 Bt-NEDD8 conjugated species detected with streptavidin-HRP. Western blot of biotinylated-NEDD8 thioester assay. Bt-NEDD8 conjugated to UbcH12 in the presence of NEDD8 E1 . Bt-NEDD8 conjugated species detected with streptavidin-HRP.

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Additional Information :
| Formulation Lyophilized. Contains PBS. | MW ~11kDa (based on Bt3-NEDD8 as predominant form present). | Reconstitution Reconstitute with sterile distilled water. | Source Produced in E. coli. | Technical Info / Product Notes Biotinylated mature protein for NEDD8 conjugation and NEDDylation pathway studies. Suggested uses: Ready detection of NEDD8 modification of specific proteins in vitro.Demonstration that novel proteins are potential targets for NEDDylation under in vitro conditions.Purification of NEDD8-conjugates via streptavidin affinity chromatography. | UniProt ID Q15843

Benzyl Penicillinate-d7 Potassium Salt Penicillin G-d7 Potassium Salt

Product Name :
Benzyl Penicillinate-d7 Potassium Salt Penicillin G-d7 Potassium Salt

Description:
Product information

CAS:
352323-25-2

Molecular Weight:
379.52

Formula:
C16H17KN2O4S

Chemical Name:
potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{2-[(2,3,4,5,6-²H₅)phenyl](2,2-²H₂)acetamido}-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Smiles :
[K+].[2H]C([2H])(C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C([O-])=O)N2C1=O)C1C([2H])=C([2H])C([2H])=C([2H])C=1[2H]

InChiKey:
IYNDLOXRXUOGIU-RSWIJXEESA-M

InChi :
InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1/i3D,4D,5D,6D,7D,8D2;

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Product information|CAS Number: 352323-25-2|Molecular Weight: 379.52|Formula: C16H17KN2O4S|Chemical Name: potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{2-[(2,3,4,5,6-²H₅)phenyl](2,2-²H₂)acetamido}-4-thia-1-azabicyclo[3.{{Hirudin} MedChemExpress|{Hirudin} Apoptosis|{Hirudin} Technical Information|{Hirudin} Data Sheet|{Hirudin} manufacturer|{Hirudin} Autophagy} 2.{{Rucaparib} MedChemExpress|{Rucaparib} Epigenetics|{Rucaparib} Technical Information|{Rucaparib} References|{Rucaparib} custom synthesis|{Rucaparib} Epigenetics} 0]heptane-2-carboxylate|Smiles: [K+].PMID:32310431 [2H]C([2H])(C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C([O-])=O)N2C1=O)C1C([2H])=C([2H])C([2H])=C([2H])C=1[2H]|InChiKey: IYNDLOXRXUOGIU-RSWIJXEESA-M|InChi: InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1/i3D,4D,5D,6D,7D,8D2;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Mineralocorticoid (aldosterone) receptor monoclonal antibody (H10E4C9F)

Product Name :
Mineralocorticoid (aldosterone) receptor monoclonal antibody (H10E4C9F)

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Additional Information :
| Alternative Name MR | Application FUNC, ICC, IHC (PS), WB | Application Notes Detects a band of ~116kDa by Western blot.{{1079774-23-4} site|{1079774-23-4} Protocol|{1079774-23-4} In Vivo|{1079774-23-4} supplier} Functional Application: Blocks the binding of aldosterone to the MR.Not suitable for immunoprecipitation.{{1610943-06-0} medchemexpress|{1610943-06-0} Biological Activity|{1610943-06-0} Formula|{1610943-06-0} supplier} | Clone H10E4C9F | Formulation Liquid.PMID:30000199 Purified ascites in PBS containing 0.05% sodium azide. | Host Mouse | Immunogen Aldosterone. | Isotype IgG1 | Recommendation Dilutions/Conditions Immunohistochemistry (paraffin sections, 1:100; staining is blocked by pre-incubating the sample with aldosterone)Western Blot (1:1,000; ECL: Enhanced detection systems like enhanced chemiluminescence are recommended).Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Produced using the anti-idiotypic method. | Species Reactivity Chicken, Human, Rabbit, Rat | UniProt ID P08235 (human), P22199 (rat) | Unit of Measure (UM) µl

LPS from Salmonella minnesota R7 (Rd) (TLRGRADE®) (Ready-to-Use)

Product Name :
LPS from Salmonella minnesota R7 (Rd) (TLRGRADE®) (Ready-to-Use)

Sequence:

Purity:
Absence of detectable protein or DNA contaminants with agonistic TLR activity.

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Use/Stability :
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +4°C.

Description:
TLR4 activator

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Additional Information :
| Activity Strong activator of Toll-like receptor 4 (TLR4). Does not activate TLR2 or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice. No further re-extraction required.Smooth (S)-form LPS are commonly the preferred choice for whole animal studies, whereas Rough (R)-form LPS are primarily used in cellular in vitro activation studies.{{2417302-07-7} site|{2417302-07-7} Biological Activity|{2417302-07-7} Purity|{2417302-07-7} custom synthesis} | Alternative Name Lipopolysaccharide from Salmonella minnesota R7 (Rd) | Couple Target TLR, TLR4 | Couple Type Activator, Ligand | Formulation Liquid.{{115144-35-9} site|{115144-35-9} Technical Information|{115144-35-9} Purity|{115144-35-9} manufacturer} Sterile, ready-to-use solution in pyrogen-free double distilled water.PMID:30252235 | Purity Absence of detectable protein or DNA contaminants with agonistic TLR activity. | Source Rough (R)-form LPS isolated and purified from Salmonella minnesota R7 (Rd mutant) by a modification of the PCP extraction method, converted to the uniform sodium salt form and dissolved in sterile pyrogen-free double distilled water. | Unit of Measure (UM) ml

Acridine Orange 10-Nonyl Bromide

Product Name :
Acridine Orange 10-Nonyl Bromide

Description:
Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm).

CAS:
75168-11-5

Molecular Weight:
472.50

Formula:
C26H38BrN3

Chemical Name:
3,6-bis(dimethylamino)-10-nonylacridin-10-ium bromide

Smiles :
[Br-].CCCCCCCCC[N+]1C2=CC(=CC=C2C=C2C=CC(=CC=12)N(C)C)N(C)C

InChiKey:
DRBHTUDHPPBMCD-UHFFFAOYSA-M

InChi :
InChI=1S/C26H38N3.BrH/c1-6-7-8-9-10-11-12-17-29-25-19-23(27(2)3)15-13-21(25)18-22-14-16-24(28(4)5)20-26(22)29;/h13-16,18-20H,6-12,17H2,1-5H3;1H/q+1;/p-1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm).|Product information|CAS Number: 75168-11-5|Molecular Weight: 472.50|Formula: C26H38BrN3|Chemical Name: 3,6-bis(dimethylamino)-10-nonylacridin-10-ium bromide|Smiles: [Br-].CCCCCCCCC[N+]1C2=CC(=CC=C2C=C2C=CC(=CC=12)N(C)C)N(C)C|InChiKey: DRBHTUDHPPBMCD-UHFFFAOYSA-M|InChi: InChI=1S/C26H38N3.BrH/c1-6-7-8-9-10-11-12-17-29-25-19-23(27(2)3)15-13-21(25)18-22-14-16-24(28(4)5)20-26(22)29;/h13-16,18-20H,6-12,17H2,1-5H3;1H/q+1;/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (52.{{Dolutegravir} medchemexpress|{Dolutegravir} Metabolic Enzyme/Protease|{Dolutegravir} Purity & Documentation|{Dolutegravir} Formula|{Dolutegravir} custom synthesis|{Dolutegravir} Cancer} 91 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm) which can be used to quantify the cardiolipin in isolated mitochondria.{{Phosphatidylethano lamine} medchemexpress|{Phosphatidylethano lamine} Metabolic Enzyme/Protease|{Phosphatidylethano lamine} Technical Information|{Phosphatidylethano lamine} Data Sheet|{Phosphatidylethano lamine} supplier|{Phosphatidylethano lamine} Cancer} when Acridine Orange 10-Nonyl Bromide interacts with cardiolipin, the dye excitation and emission wave lengths shift from 496 and 525 nm to 450 and 640 nm, respectively.PMID:33125288 Increasing amounts of cardiolipin (0 to 30 μM) and other acidic phospholipids in thin-walled vesicles added to Acridine Orange 10-Nonyl Bromide (45 μM) changes the red fluorescence emission measured at 640 nm according to the liposome composition.|Products are for research use only. Not for human use.|

INSM1 monoclonal antibody (A-8)

Product Name :
INSM1 monoclonal antibody (A-8)

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Description:
INSM1 (A-8) Mouse Monoclonal Antibody is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. INSM1 (Insulinoma-associated protein 1) is a transcription factor primarily known for its role in neuroendocrine differentiation and development. It is expressed in various neuroendocrine tissues and tumors, including pancreatic neuroendocrine tumors (NETs), neuroendocrine lung tumors, and neuroendocrine carcinomas of the gastrointestinal tract. INSM1 plays a crucial role in regulating the expression of genes involved in neuroendocrine cell fate determination, differentiation, and hormone production. Its expression pattern and potential diagnostic and prognostic significance make it a valuable biomarker in neuroendocrine tumor pathology and research. Formalin fixed paraffin embedded human pancreas stained with INSM1 antibody, 25x Formalin fixed paraffin embedded human pancreas stained with INSM1 antibody, 25x

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Solubility:

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Additional Information :
| Alternative Name Insulinoma-associated protein 1 | Application IHC (PS) | Application Notes Pretreatment: Tris/EDTA Buffer pH 8.{{130308-48-4} medchemexpress|{130308-48-4} Protocol|{130308-48-4} In Vivo|{130308-48-4} supplier} 0 | Clone A-8 | Formulation This product is supplied as an immunoglobulin and contains sodium azide as a preservative | Host Mouse | Immunogen Amino acid 81-125 at the N-terminus of human INSM1 | Isotype IgG1, kappa | Positive Control Neuroendocrine tumor | Recommendation Dilutions/Conditions 1:50 – 1:200Antibody dilutions should be appropriately adjusted and verified according to the detection system used.{{2883540-92-7} web|{2883540-92-7} Biological Activity|{2883540-92-7} In stock|{2883540-92-7} manufacturer} Optimal conditions must be determined individually for each application.PMID:31424829 | Species Reactivity Human | Unit of Measure (UM) ml, µl

HSP70/HSP72 polyclonal antibody

Product Name :
HSP70/HSP72 polyclonal antibody

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Description:
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.{{1691249-45-2} MedChemExpress|{1691249-45-2} Biological Activity|{1691249-45-2} References|{1691249-45-2} supplier} Western blot analysis of HSP70 pAb: Lane 1: HSP70 (HSP72) Recombinant Human Protein, Lane 2: HSC70 (HSP73) Recombinant Bovine Protein (negative control), Lane 3: HeLa Cell Lysate, Heat Shocked, Lane 4: PC-12 Cell Lysate, Heat Shocked, Lane 5: Vero Cell Lysate, Heat Shocked, Lane 6: CHO-K1 Cell Lysate, Heat Shocked Western blot analysis of HSP70 pAb: Lane 1: HSP70 (HSP72) Recombinant Human Protein, Lane 2: HSC70 (HSP73) Recombinant Bovine Protein (negative control), Lane 3: HeLa Cell Lysate, Heat Shocked, Lane 4: PC-12 Cell Lysate, Heat Shocked, Lane 5: Vero Cell Lysate, Heat Shocked, Lane 6: CHO-K1 Cell Lysate, Heat Shocked

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Additional Information :
| Alternative Name Hsp70, HspA1A, Heat shock protein 70, HspA1B, Hsp72 | Application IP, WB | Application Notes Detects a band of ~70kDa by Western blot.{{2760481-53-4} medchemexpress|{2760481-53-4} Purity & Documentation|{2760481-53-4} References|{2760481-53-4} manufacturer} | Formulation Liquid.PMID:29261870 In PBS containing 50% glycerol and 0.09% sodium azide. | GenBank ID M11717 | Gene/Protein Identifier NP_005336.3 (RefSeq), NM_005345 (RefSeq), 3303 (Entrez GeneID), 140550 (OMIM) | Host Rabbit | Immunogen Synthetic peptide corresponding to a portion of human Hsp70. | Recommendation Dilutions/Conditions Western Blot (1:1,000, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from rabbit serum. | Species Reactivity Beluga, Bovine, Dog, Hamster, Human, Monkey, Mouse, Porcine, Rat, Sheep | UniProt ID P0DMV8 (HSPA1A), P0DMV9 (HSPA1B) | Unit of Measure (UM) µg

HSR6071

Product Name :
HSR6071

Description:
HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.

CAS:
111374-21-1

Molecular Weight:
260.26

Formula:
C10H12N8O

Chemical Name:
6-(pyrrolidin-1-yl)-N-(2H-1,2,3,4-tetrazol-5-yl)pyrazine-2-carboxamide

Smiles :
O=C(NC1N=NNN=1)C1=CN=CC(=N1)N1CCCC1

InChiKey:
LUJDHCXCWJFNOJ-UHFFFAOYSA-N

InChi :
InChI=1S/C10H12N8O/c19-9(13-10-14-16-17-15-10)7-5-11-6-8(12-7)18-3-1-2-4-18/h5-6H,1-4H2,(H2,13,14,15,16,17,19)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Purmorphamine} web|{Purmorphamine} Activator|{Purmorphamine} Epigenetics|{Purmorphamine} Biological Activity|{Purmorphamine} In Vivo|{Purmorphamine} supplier}

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models.|Product information|CAS Number: 111374-21-1|Molecular Weight: 260.26|Formula: C10H12N8O|Chemical Name: 6-(pyrrolidin-1-yl)-N-(2H-1,2,3,4-tetrazol-5-yl)pyrazine-2-carboxamide|Smiles: O=C(NC1N=NNN=1)C1=CN=CC(=N1)N1CCCC1|InChiKey: LUJDHCXCWJFNOJ-UHFFFAOYSA-N|InChi: InChI=1S/C10H12N8O/c19-9(13-10-14-16-17-15-10)7-5-11-6-8(12-7)18-3-1-2-4-18/h5-6H,1-4H2,(H2,13,14,15,16,17,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clavulanate} site|{Clavulanate} Antibiotic|{Clavulanate} Biological Activity|{Clavulanate} In Vitro|{Clavulanate} manufacturer|{Clavulanate} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:33156798 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea. HSR-6071 inhibits the IgE-mediated histamine release with an IC50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract.|Products are for research use only. Not for human use.|