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Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.|Product information|CAS Number: 548-83-4|Molecular Weight: 270.24|Formula: C15H10O5|Chemical Name: 3,5,7-trihydroxy-2-phenyl-4H-chromen-4-one|Smiles: OC1C(=O)C2C(=CC(O)=CC=2O)OC=1C1C=CC=CC=1|InChiKey: VCCRNZQBSJXYJD-UHFFFAOYSA-N|InChi: InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (462.55 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Galangin (Norizalpinin) inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner.Encenicline custom synthesis Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD).Palivizumab supplier Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter.PMID:33287588 Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.|Products are for research use only. Not for human use.|

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(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.|Product information|CAS Number: 54276-21-0|Molecular Weight: 424.GLP-1(7-36), amide GCGR 92|Formula: C22H29ClO6|Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid|Smiles: OC(=O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COC2C=CC=C(Cl)C=2)[C@H](O)C[C@@H]1O|InChiKey: VJGGHXVGBSZVMZ-QIZQQNKQSA-N|InChi: InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (235.Pimicotinib Protein Tyrosine Kinase/RTK 34 mM; Need ultrasonic).PMID:33356512 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P In Vivo:|D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch.|Products are for research use only. Not for human use.|

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ARQ 621 is an allosteric, potent and selective inhibitor of Eg5, a microtubule-based ATPase motor protein involved in cell division. Anti-tumor activity. ARQ 621 is a kinesin inhibitor.|Product information|CAS Number: 1095253-39-6|Molecular Weight: 552.43|Formula: C28H24Cl2FN5O2|Chemical Name: N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylamino)-3,4-dihydroquinazolin-2-yl]but-3-yn-1-yl]-2-fluorobenzamide|Smiles: C#CC[C@H](C1=NC2C=C(Cl)C=CC=2C(=O)N1NC1C=CC=CC=1)N(CCCN)C(=O)C1C=CC=C(Cl)C=1F|InChiKey: UPJSUQWHUVLLNW-XMMPIXPASA-N|InChi: InChI=1S/C28H24Cl2FN5O2/c1-2-8-24(35(16-7-15-32)27(37)21-11-6-12-22(30)25(21)31)26-33-23-17-18(29)13-14-20(23)28(38)36(26)34-19-9-4-3-5-10-19/h1,3-6,9-14,17,24,34H,7-8,15-16,32H2/t24-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.AUDA Description |Shelf Life: ≥12 months if stored properly.Axitinib custom synthesis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33356512 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Over-expression of Eg5 causes genomic instability and tumor formation in mice; therefore, Eg5 is a potential anti-cancer target.|Products are for research use only. Not for human use.|

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Doramapimod, also known as BIRB-796, is a member of the N-pyrazole-N’-naphthly urea class of p38MAPK inhibitors, which binds to the kinase with both slow association and dissociation rates. BIRB -796 has entered clinical trials for the treatment of autoimmune diseases.|Product information|CAS Number: 285983-48-4|Molecular Weight: 527.66|Formula: C31H37N5O3|Chemical Name: 3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-ylurea|Smiles: CC1C=CC(=CC=1)N1N=C(C=C1NC(=O)NC1=CC=C(OCCN2CCOCC2)C2=CC=CC=C12)C(C)(C)C|InChiKey: MVCOAUNKQVWQHZ-UHFFFAOYSA-N|InChi: InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Ginkgolic Acid Biological Activity |Shelf Life: ≥360 days if stored properly.Foscarbidopa Epigenetics |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33349091 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.|Product information|CAS Number: 912367-45-4|Molecular Weight: 366.48|Formula: C20H22N4OS|Chemical Name: 4-[(2R,3S)-2-methylpiperidin-3-yl]amino-2-phenylthieno[3,2-c]pyridine-7-carboxamide|Smiles: C[C@H]1NCCC[C@@H]1NC1N=CC(C(N)=O)=C2SC(=CC2=1)C1C=CC=CC=1|InChiKey: LMQOZGSVTQQPFU-WBMJQRKESA-N|InChi: InChI=1S/C20H22N4OS/c1-12-16(8-5-9-22-12)24-20-14-10-17(13-6-3-2-4-7-13)26-18(14)15(11-23-20)19(21)25/h2-4,6-7,10-12,16,22H,5,8-9H2,1H3,(H2,21,25)(H,23,24)/t12-,16+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Solithromycin medchemexpress |Shelf Life: ≥12 months if stored properly.PMID:32119308 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents.|Products are for research use only. Not for human use.|