For the presence of hepatitis B virus in liver cells, even though the organism itself is just not cytophatic (Ryan and Ray, 2004). During hepatitis B infection, many virus particles are released from infected liver cells, resulting in massive volume of viral antigen entering the blood. Hepatitis B surface antigen(HBsAg) is present in about two weeks prior to the onset of symptoms and persists all through the course with the disease (Cheesbrough, 2002). At the recovery, it declines and is no PD-1 Protein Human longer detectable right after four five months. Persistence of HBsAg beyond six months indicates chronic infection or carrier state (Lok and McMahon, 2001: Cheesbrough, 2002). Detectable antigens of hepatitis B virus also include things like; hepatitis B envelope antigen (HBeAg) a SIRP beta 1 Protein HEK 293 secreted product on the nucleocapsid gene of hepatitis B virus through chronic hepatitis B virus infection and its presence indicates that the virus is replicating and also the infected person features a high level of hepatitis B virus. The other kind of the antigen is hepatitis B core antigen (HBcAg) which is secreted by inner nucleocapsid core that encases the genome (Lai et al., 2003). Structural proteins such as pre-S1 and pre-S2 are regions involved in hepatitis B virus binding and entry into the hepatocytes. Hepatitis B envelope antibody (anti-HBe) is developed by immune technique temporarily through acuteResearch Articlehepatitis B virus infection or regularly through or immediately after a burst of viral replication. It may be found in the convalescence stage and often in chronic hepatitis as well as the carrier state (Lai et al., 2003). It is actually believed that the antibody response to viral envelope antigens contributes to clearance with the virus and that cytotoxic T cells mediate viral clearance by killing the infected cell (Francis, 1999). Alao et al. (2009) analyzed the results of HBsAg screening among blood donors in general Hospital, Otukpo, an urban region of Benue State, over a three-year period (2006 2008), with a view to establishing the prevalence rate within this area from the Middle Belt of Nigeria. two,500 samples have been screened for HBsAg over the three-year period. The seropositivity price amongst donors tested was found to become 20 . Hepatitis B virus has the same routes of transmission as Human Immunodeficiency Virus (HIV) and Hepatitis C Virus hence the coinfection of one particular or both of your agents with HBV is feasible. It has been demonstrated in clinical studies that HIV infection causes a a lot more fast progression of chronic hepatitis C / hepatitis B to cirrhosis and liver failure (Ryan and Ray, 2004; Olusoji et al., 2006; CROI, 2008). This investigation work was thus created to evaluate the frequency of occurrence of HBeAg, anti-HBe, anti-HIV and anti-HCV inside the preicteric, icteric and posticteric HBsAg seropositive patients.Biology and Medicine, 2 (three): 14-25,Ibadan for at the very least 5 years classified into preicteric (n=13;aged 6 – 72 years), icteric (n = 16; aged 6 – 76 years) and posticteric (n = 14; aged six – 76 years) individuals were also investigated along with the benefits obtained have been applied as urban reference data. Rural subjects had been recruited from SakiWest/Saki-East/ATISBO federal constituency of Oyo North Senatorial District, Nigeria Volunteers which have been living in this region for not less than 5 years were studied. The important complaints of the critically ill Preicteric and Posticteric patients volunteered towards the clinician as well as the researcher had been malaise, abdominal tenderness/pain, prolong headache, nausea/vomiting and loss of appetite. Abo.