Product Name :
CDK12-IN-5
Description:
CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1).
CAS:
2651200-35-8
Molecular Weight:
454.36
Formula:
C18H15F5N8O
Chemical Name:
N-((6, 7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-8-(trifluoromethyl)pyrazolo[1, 5-a][1, 3, 5]triazin-4-amine
Smiles :
FC(F)(F)C1C=NN2C(NCC3NC4=C(C=CC(F)=C4F)N=3)=NC(=NC2=1)N1CCOCC1
InChiKey:
XFZQHKMIWRKKCU-UHFFFAOYSA-N
InChi :
InChI=1S/C18H15F5N8O/c19-10-1-2-11-14(13(10)20)27-12(26-11)8-24-16-29-17(30-3-5-32-6-4-30)28-15-9(18(21,22)23)7-25-31(15)16/h1-2,7H,3-6,8H2,(H,26,27)(H,24,28,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Ibotenic acid} MedChemExpress|{Ibotenic acid} Membrane Transporter/Ion Channel|{Ibotenic acid} Protocol|{Ibotenic acid} Purity|{Ibotenic acid} manufacturer|{Ibotenic acid} Cancer}
Additional information:
CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1).|Product information|CAS Number: 2651200-35-8|Molecular Weight: 454.36|Formula: C18H15F5N8O|Chemical Name: N-((6, 7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-8-(trifluoromethyl)pyrazolo[1, 5-a][1, 3, 5]triazin-4-amine|Smiles: FC(F)(F)C1C=NN2C(NCC3NC4=C(C=CC(F)=C4F)N=3)=NC(=NC2=1)N1CCOCC1|InChiKey: XFZQHKMIWRKKCU-UHFFFAOYSA-N|InChi: InChI=1S/C18H15F5N8O/c19-10-1-2-11-14(13(10)20)27-12(26-11)8-24-16-29-17(30-3-5-32-6-4-30)28-15-9(18(21,22)23)7-25-31(15)16/h1-2,7H,3-6,8H2,(H,26,27)(H,24,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Neuromedin B} medchemexpress|{Neuromedin B} Endogenous Metabolite|{Neuromedin B} Technical Information|{Neuromedin B} Data Sheet|{Neuromedin B} custom synthesis|{Neuromedin B} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:34816786 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CDK12-IN-5 (Example 426) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=3.23 nM) and has no effect on CAL-120 cells. CDK12-IN-5 has antproliferative activity in MDA-MB-231 cells (IC50=4.19 nM) and CAL-120 cells (IC50=3.57 nM). CDK12-IN-5 has a inhibition IC50 CDK12 high ATP to Degradation DC50 CDK12 ratio of 32.|Products are for research use only. Not for human use.|