Product Name :
Fmoc-8-amino-3, 6-dioxaoctanoic acid
Description:
Fmoc-8-amino-3, 6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3, 6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
CAS:
166108-71-0
Molecular Weight:
385.41
Formula:
C21H23NO6
Chemical Name:
2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid
Smiles :
OC(=O)COCCOCCNC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21
InChiKey:
XQPYRJIMPDBGRW-UHFFFAOYSA-N
InChi :
InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fmoc-8-amino-3, 6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).{{Mephenytoin} MedChemExpress|{Mephenytoin} Metabolic Enzyme/Protease|{Mephenytoin} TGF-beta/Smad|{Mephenytoin} Technical Information|{Mephenytoin} Description|{Mephenytoin} manufacturer} Fmoc-8-amino-3, 6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.{{Nourseothricin} site|{Nourseothricin} Inhibitor|{Nourseothricin} NF-κB|{Nourseothricin} Technical Information|{Nourseothricin} In stock|{Nourseothricin} manufacturer} |Product information|CAS Number: 166108-71-0|Molecular Weight: 385.41|Formula: C21H23NO6|Synonym:|Fmoc-NH-PEG2-CH2COOH|Chemical Name: 2-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]ethoxy}acetic acid|Smiles: OC(=O)COCCOCCNC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21|InChiKey: XQPYRJIMPDBGRW-UHFFFAOYSA-N|InChi: InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32463711 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Nakamura A, et al. Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules. Biochemistry. 2020 Jan 21;59(2):205-211.Products are for research use only. Not for human use.|